DESCRIBE <http://purl.uniprot.org/citations/18085638>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18085638	http://www.w3.org/2000/01/rdf-schema#comment	" Background The poor prognosis for elderly patients with acute myeloid leukemia (AML) raises questions regarding the benefit of treating them with intensive chemotherapy. The impact of initial characteristics on prognosis has been addressed previously in elderly patients; however, very few data are available regarding the prognostic value of immunophenotypic characteristics in this setting. Methods The authors investigated expression of the membrane antigens CD13, CD15, CD33, and CD34 by flow cytometry in elderly patients with newly diagnosed AML and analyzed whether these parameters had clinical or prognostic relevance to help physicians in their choice of therapy. Results Immunophenotyping was performed in 273 patients aged > or =60 years (median age, 69 years). CD13 was expressed in 73% of patients, CD15 was expressed in 43% of patients, CD33 was expressed in 64% of patients, and CD34 was expressed in 66% of patients. Complete remission was obtained in 157 patients (58%). The median overall survival was 8.1 months, and the 3-year survival rate was 14%. Three risk groups were defined based on CD34 and CD33 antigen expression: The poor-risk group included patients with CD34-positive/CD33-positive or CD34-negative/CD33-negative disease, the intermediate-risk group included patients with CD34-positive/CD33-negative disease, and the favorable-risk group included patients with CD34-negative/CD33-positive disease. After cytogenetic analyses, immunophenotype was the most significant prognostic factor in terms of survival in a multivariate analysis (P = .03 and P < .0001, respectively). When immunophenotypic and cytogenetic parameters were combined, patients were classified into 4 prognostic groups: Group A (3-year survival rate, 33%) included patients with favorable and normal karyotypes who had a favorable immunophenotype, Group B (3-year survival rte, 28%) included patients with normal karyotypes who had an intermediate immunophenotype, Group C (3-year survival rate, 8%) included patients with intermediate or normal karyotypes who had an unfavorable immunophenotype, and Group D (3-year survival rate, 2%) included all patients who had unfavorable cytogenetics. Conclusions Immunophenotypic characteristics appeared to be a major prognostic factor in this population of elderly patients with AML. By using 2 simple parameters assessed at the time of diagnosis, the authors devised a prognostic system of immediate clinical utility for prognostic stratification and risk-adapted therapeutic choices."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.org/dc/terms/identifier	"doi:10.1002/cncr.23219"xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Tigaud I."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Thomas X."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Dumontet C."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Michallet M."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Chelghoum Y."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Elhamri M."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Plesa A."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/author	"Plesa C."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/name	"Cancer"xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/pages	"572-580"xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/title	"Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience."xsd:string
http://purl.uniprot.org/citations/18085638	http://purl.uniprot.org/core/volume	"112"xsd:string
http://purl.uniprot.org/citations/18085638	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18085638
http://purl.uniprot.org/citations/18085638	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18085638
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http://purl.uniprot.org/uniprot/#_B4DG27-mappedCitation-18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18085638
http://purl.uniprot.org/uniprot/#_A8KAG5-mappedCitation-18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18085638
http://purl.uniprot.org/uniprot/#_B4DP01-mappedCitation-18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18085638
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http://purl.uniprot.org/uniprot/#_B4DV63-mappedCitation-18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18085638
http://purl.uniprot.org/uniprot/#_B4DF51-mappedCitation-18085638	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18085638