| http://purl.uniprot.org/citations/18086569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18086569 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-bullous congenital ichthyosis erythroderma (NCIE) and lamellar ichthyosis (LI) are characterized by mutations in 12R-lipoxygenase (12R-LOX) and/or epidermal lipoxygenase 3 (eLOX3) enzymes. The eLOX3 lacks oxygenase activity, but is capable of forming hepoxilin-type products from arachidonic acid-derived hydroperoxide from 12R-LOX, termed 12R-hydroperoxyeicosa-5,8,10,14-tetraenoic acid (12R-HpETE). Mutations in either of two enzymes lead to NCIE or LI. Moreover, 12R-LOX-deficient mice exhibit severe phenotypic water barrier dysfunctions. Here, we demonstrate that 12R-HpETE can also be transformed to 8R-HXA(3) by hepoxilin A(3) (HXA(3)) synthase (12-lipoxygenase), which exhibits oxygenase activity. We also presented a novel form of ichthyosis in a patient, termed hepoxilin A(3) synthase-linked ichthyosis (HXALI), whose scales expressed high levels of 12R-LOX, but were deficient of HXA(3) synthase."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.12.017"xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Lohse M."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Nigam S."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Ciccoli R."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Zafiriou M.P."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Deva R."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Geilen C."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Kerstin N."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/author | "Sczepanski M."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/pages | "279-285"xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/title | "Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form."xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://purl.uniprot.org/core/volume | "582"xsd:string |
| http://purl.uniprot.org/citations/18086569 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18086569 |
| http://purl.uniprot.org/citations/18086569 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18086569 |
| http://purl.uniprot.org/uniprot/#_Q16120-mappedCitation-18086569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18086569 |
| http://purl.uniprot.org/uniprot/#_P18054-mappedCitation-18086569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18086569 |
| http://purl.uniprot.org/uniprot/#_O75342-mappedCitation-18086569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18086569 |
| http://purl.uniprot.org/uniprot/Q16120 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18086569 |
| http://purl.uniprot.org/uniprot/P18054 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18086569 |
| http://purl.uniprot.org/uniprot/O75342 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18086569 |