| http://purl.uniprot.org/citations/18086858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18086858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18086858 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenin plays important roles in cell adhesion and gene transcription, and has been shown recently to be essential for the establishment of a bipolar mitotic spindle. Here we show that beta-catenin is a component of interphase centrosomes and that stabilization of beta-catenin, mimicking mutations found in cancers, induces centrosome splitting. Centrosomes are held together by a dynamic linker regulated by Nek2 kinase and its substrates C-Nap1 (centrosomal Nek2-associated protein 1) and Rootletin. We show that beta-catenin binds to and is phosphorylated by Nek2, and is in a complex with Rootletin. In interphase, beta-catenin colocalizes with Rootletin between C-Nap1 puncta at the proximal end of centrioles, and this localization is dependent on C-Nap1 and Rootletin. In mitosis, when Nek2 activity increases, beta-catenin localizes to centrosomes at spindle poles independent of Rootletin. Increased Nek2 activity disrupts the interaction of Rootletin with centrosomes and results in binding of beta-catenin to Rootletin-independent sites on centrosomes, an event that is required for centrosome separation. These results identify beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1596308"xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1596308"xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Casey P.J."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Casey P.J."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Winey M."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Winey M."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Giddings T.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Giddings T.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Salmon E.D."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Salmon E.D."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Bahmanyar S."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Bahmanyar S."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "O'Toole E.T."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "O'Toole E.T."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Deluca J.G."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Deluca J.G."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Kaplan D.D."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Kaplan D.D."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Barth A.I."xsd:string |
| http://purl.uniprot.org/citations/18086858 | http://purl.uniprot.org/core/author | "Barth A.I."xsd:string |