| http://purl.uniprot.org/citations/18086896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18086896 | http://www.w3.org/2000/01/rdf-schema#comment | "Fanconi anemia (FA) is a cancer susceptibility syndrome characterized by defective DNA interstrand cross-link (ICL) repair. Here, we show that DOG-1 is the Caenorhabditis elegans homologue of FANCJ, a helicase mutated in FA-J patients. DOG-1 performs a conserved role in ICL repair, as dog-1 mutants are hypersensitive to ICL-inducing agents, but not to UVC irradiation or X rays. Genetic analysis indicated that dog-1 is epistatic with fcd-2 (C. elegans FANCD2) but is nonepistatic with brc-1 (C. elegans BRCA1), thus establishing the existence of two distinct pathways of ICL repair in worms. Furthermore, DOG-1 is dispensable for FCD-2 and RAD-51 focus formation, suggesting that DOG-1 operates downstream of FCD-2 and RAD-51 in ICL repair. DOG-1 was previously implicated in poly(G)/poly(C) (G/C) tract maintenance during DNA replication. G/C tracts remain stable in the absence of ATL-1, CLK-2 (FA pathway activators), FCD-2, BRC-2, and MLH-1 (associated FA components), implying that DOG-1 is the sole FA component required for G/C tract maintenance in a wild-type background. However, FCD-2 is required to promote deletion-free repair at G/C tracts in dog-1 mutants, consistent with a role for FA factors at the replication fork. The functional conservation between DOG-1 and FANCJ suggests a possible role for FANCJ in G/C tract maintenance in human cells."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01641-07"xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Boulton S.J."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "O'Neil N.J."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Rose A.M."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Ward J.D."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Collis S.J."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Barber L.J."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/author | "Youds J.L."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/pages | "1470-1479"xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/title | "DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair."xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18086896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18086896 |
| http://purl.uniprot.org/citations/18086896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18086896 |
| http://purl.uniprot.org/uniprot/B6VQ60#attribution-9518DA40AF31836A250A5838FED35689 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |
| http://purl.uniprot.org/uniprot/O62217#attribution-9518DA40AF31836A250A5838FED35689 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |
| http://purl.uniprot.org/uniprot/Q9U2H4#attribution-9518DA40AF31836A250A5838FED35689 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |
| http://purl.uniprot.org/uniprot/Q9U2H4#attribution-CE5E438492200D3345CE46992BA6C7FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |
| http://purl.uniprot.org/uniprot/D3YT99#attribution-9518DA40AF31836A250A5838FED35689 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |
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| http://purl.uniprot.org/uniprot/E5QCJ4#attribution-CE5E438492200D3345CE46992BA6C7FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18086896 |