| http://purl.uniprot.org/citations/18089783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18089783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18089783 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor cells often aberrantly reexpress molecules that mediate proper embryonic development for advantageous growth or survival. Here, we report that ankyrin repeat-rich membrane spanning (ARMS), a transmembrane protein abundant in the developing and adult neural tissues, is overexpressed in melanoma, a tumor ontogenetically originating from neural crest. Immunohistochemical study of 79 melanocytic lesions showed significantly increased expression of ARMS in primary malignant melanomas (92.9%) and metastatic melanoma (60.0%) in comparison with benign nevocellular nevi (26.7%). To investigate the role of ARMS in melanoma formation, murine B16F0 melanoma cells with stable knockdown of ARMS were established by RNA interference. Down-regulation of ARMS resulted in significant inhibition of anchorage-independent growth in soft agar and restrictive growth of melanoma in severe combined immunodeficient mice. Importantly, depletion of ARMS facilitated UVB-induced apoptosis in melanoma cells through inactivation of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK. Addition of MEK inhibitor PD98059 further sensitized ARMS-depleted melanoma cells to UVB-induced apoptosis, whereas constitutively active MEK rescued ARMS-depleted cells from apoptosis. We further showed that BRAF, a downstream signaling molecule of ARMS in ERK pathway, is not mutated as a constitutively active form in acral lentiginous melanoma; in contrast, BRAF(T1799A) mutation, which leads to constitutive activation of ERK signaling, was detected in 57.1% of superficial spreading melanoma. Our study suggests that overexpression of ARMS per se serves as one mechanism to promote melanoma formation by preventing stress-induced apoptotic death mediated by the MEK/ERK signaling pathway, especially in acral lentiginous melanoma, most of which does not harbor BRAF mutation."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1930"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1930"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Huang P.-H."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Huang P.-H."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Hsu S.-M."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Hsu S.-M."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Liao Y.-H."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/author | "Liao Y.-H."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/pages | "11547-11556"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/pages | "11547-11556"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/title | "ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/title | "ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/18089783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18089783 |
| http://purl.uniprot.org/citations/18089783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18089783 |
| http://purl.uniprot.org/citations/18089783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18089783 |
| http://purl.uniprot.org/citations/18089783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18089783 |