| http://purl.uniprot.org/citations/18089822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18089822 | http://www.w3.org/2000/01/rdf-schema#comment | "B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor that plays an important role during plasmacytic differentiation and is expressed in normal and transformed plasma cells. We here investigated the importance of continuous Blimp-1 expression. We found that knockdown of Blimp-1 expression by lentiviral vector-delivered short hairpin RNA causes apoptosis in multiple myeloma cell lines and plasmacytoma cells, indicating that continued expression of Blimp-1 is required for cell survival. We examined the mechanism underlying Blimp-1 knockdown-mediated apoptosis and found that the Blimp-1 knockdown neither reversed the phenotypic markers of plasma cells nor caused cell cycle arrest. Instead, our results show that knockdown of Blimp-1 induced the proapoptotic protein Bim, reduced the antiapoptotic protein Mcl-1, and activated caspase-9 and caspase-3. We further link apoptosis in transformed plasma cells mediated by proteasome inhibitors, the effective therapeutic agent for multiple myeloma patients, with reduced expression of Blimp-1. Lastly, we show that Blimp-1-dependent cell survival may act downstream of IFN regulatory factor 4 (IRF4) because IRF4 knockdown leads to down-regulation of Blimp-1 and apoptosis in multiple myeloma cells and plasmacytoma cells. Together, our data suggest that Blimp-1 ensures the survival of transformed plasma cells."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1868"xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/author | "Kuo H.K."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/author | "Lin F.R."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/author | "Lin K.I."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/author | "Ying H.Y."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/author | "Yang F.H."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/pages | "11914-11923"xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/title | "Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown."xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/18089822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18089822 |
| http://purl.uniprot.org/citations/18089822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18089822 |
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