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http://purl.uniprot.org/citations/18091530http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18091530http://www.w3.org/2000/01/rdf-schema#comment"

Background

The polymorphic family of killer-cell immunoglobulin-like receptors (KIRs) consists of activating and inhibitory receptors expressed by natural killer (NK) cells and effector T cells that recognize human leukocyte antigen (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts beneficial effects in hematopoietic stem cell transplantation.

Methods

To elucidate whether certain receptor-ligand combinations between recipient KIR and donor HLA antigens lead to enhanced alloreactivity of NK cells associated with acute rejection (aRx) after kidney transplantation, we analyzed the entirety of matches/mismatches between KIR genes and known HLA ligands for aRx patients (n=105) compared to patients with stable renal function (n=119).

Results

Whereas HLA-C ligand incompatibility between donor and recipient has no influence on aRx, grafts derived from donors homozygous for HLA-C group 2 alleles seem to demonstrate a better outcome (P=0.052). Additionally, a higher number of inhibitory receptors in the recipient's genotype (P=0.042), a significant higher number of matches for the receptors KIR2DL2/DS2 (P=0.004), as well as a higher number of mismatches for KIR2DL3 (P=0.014) could be observed for patients with stable renal function.

Conclusion

Our data illustrate that certain KIR/HLA class I ligand combinations between donor and recipient might influence graft short-term outcome after renal transplantation."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.org/dc/terms/identifier"doi:10.1097/01.tp.0000290681.41859.41"xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Neumann K."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Seiler M."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Schonemann C."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Volk H.D."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Reinke P."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Kotsch K."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Kunert K."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Mashreghi M.F."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Pratschke J."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/author"Klippert K."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/name"Transplantation"xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/pages"1527-1533"xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/title"KIR/HLA ligand incompatibility in kidney transplantation."xsd:string
http://purl.uniprot.org/citations/18091530http://purl.uniprot.org/core/volume"84"xsd:string
http://purl.uniprot.org/citations/18091530http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18091530
http://purl.uniprot.org/citations/18091530http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18091530
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