| http://purl.uniprot.org/citations/18094026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18094026 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also known as SMARCA4). We have conditionally deleted a floxed Brg1 allele with a Tie2-Cre transgene, which is expressed in developing hematopoietic and endothelial cells. Brg1(fl/fl):Tie2-Cre(+) embryos die at midgestation from anemia, as mutant primitive erythrocytes fail to transcribe embryonic alpha- and beta-globins, and subsequently undergo apoptosis. Additionally, vascular remodeling of the extraembryonic yolk sac is abnormal in Brg1(fl/fl):Tie2-Cre(+) embryos. Importantly, Brm deficiency does not exacerbate the erythropoietic or vascular abnormalities found in Brg1(fl/fl):Tie2-Cre(+) embryos, implying that Brg1-containing SWI/SNF-like complexes, rather than Brm-containing complexes, play a crucial role in primitive erythropoiesis and in early vascular development."xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.010090"xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/author | "Brennan J."xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/author | "Griffin C.T."xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/pages | "493-500"xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/title | "The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development."xsd:string |
| http://purl.uniprot.org/citations/18094026 | http://purl.uniprot.org/core/volume | "135"xsd:string |
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