| http://purl.uniprot.org/citations/18094055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18094055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18094055 | http://www.w3.org/2000/01/rdf-schema#comment | "The assembly of tight junctions (TJs) and adherens junctions (AJs) is regulated by the transport of integral TJ and AJ proteins to and/or from the plasma membrane (PM) and it is tightly coordinated in epithelial cells. We previously reported that Rab13 and a junctional Rab13-binding protein (JRAB)/molecule interacting with CasL-like 2 (MICAL-L2) mediated the endocytic recycling of an integral TJ protein occludin and the formation of functional TJs. Here, we investigated the role of Rab13 and JRAB/MICAL-L2 in the transport of other integral TJ and AJ proteins claudin-1 and E-cadherin to the PM by using a Ca(2+)-switch model. Although knockdown of Rab13 specifically suppressed claudin-1 and occludin but not E-cadherin transport, knockdown of JRAB/MICAL-L2 and expression of its Rab13-binding domain (JRAB/MICAL-L2-C) inhibited claudin-1, occludin, and E-cadherin transport. We then identified Rab8 as another JRAB/MICAL-L2-C-binding protein. Knockdown of Rab8 inhibited the Rab13-independent transport of E-cadherin to the PM. Rab8 and Rab13 competed with each other for the binding to JRAB/MICAL-L2 and functionally associated with JRAB/MICAL-L2 at the perinuclear recycling/storage compartments and PM, respectively. These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e07-06-0551"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e07-06-0551"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Sasaki T."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Nishimura N."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Nishimura N."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Nakatsuji H."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Nakatsuji H."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Yamamura R."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Yamamura R."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Arase S."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/author | "Arase S."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/pages | "971-983"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/pages | "971-983"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/title | "The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/title | "The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18094055 | http://purl.uniprot.org/core/volume | "19"xsd:string |