| http://purl.uniprot.org/citations/18094251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18094251 | http://www.w3.org/2000/01/rdf-schema#comment | "A member of regulator of G-protein signaling family, RGS9-2, is an essential modulator of signaling through neuronal dopamine and opioid G-protein-coupled receptors. Recent findings indicate that the abundance of RGS9-2 determines sensitivity of signaling in the locomotor and reward systems in the striatum. In this study we report the mechanism that sets the concentration of RGS9-2 in vivo, thus controlling G-protein signaling sensitivity in the region. We found that RGS9-2 possesses specific degradation determinants which target it for constitutive destruction by lysosomal cysteine proteases. Shielding of these determinants by the binding partner R7 binding-protein (R7BP) controls RGS9-2 expression at the posttranslational level. In addition, binding to R7BP in neurons targets RGS9-2 to the specific intracellular compartment, the postsynaptic density. Implementation of this mechanism throughout ontogenetic development ensures expression of RGS9-2/type 5 G-protein beta subunit/R7BP complexes at postsynaptic sites in unison with increased signaling demands at mature synapses."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3884-07.2007"xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Wickman K."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Song J.H."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Chen C.K."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Uversky V."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Martemyanov K.A."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Anderson G.R."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Semenov A."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Posokhova E.N."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/author | "Pravetoni M."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/pages | "14117-14127"xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/title | "Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases."xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18094251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18094251 |
| http://purl.uniprot.org/citations/18094251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18094251 |
| http://purl.uniprot.org/uniprot/Q8BQP9#attribution-045D3AB93929A8CA145D432B6DD7673F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18094251 |
| http://purl.uniprot.org/uniprot/O54828#attribution-045D3AB93929A8CA145D432B6DD7673F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18094251 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STC5-mappedCitation-18094251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18094251 |
| http://purl.uniprot.org/uniprot/#_A1L351-mappedCitation-18094251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18094251 |
| http://purl.uniprot.org/uniprot/#_A2A6V6-mappedCitation-18094251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18094251 |