| http://purl.uniprot.org/citations/18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18096998 | http://www.w3.org/2000/01/rdf-schema#comment | "Influenza pneumonia results in considerable lung injury, a significant component of which is mediated by CD8+ T cell Ag recognition in the distal airways and alveoli. TNF-alpha produced by Ag-specific CD8+ T cells appears primarily responsible for this immunopathology, and we have examined the negative regulation of CD8+ TNF production by CD94/NKG2A engagement with its receptor, Qa-1b. TNF production by antiviral CD8+ T cells was significantly enhanced by NKG2A blockade in vitro, and mice deficient in the NKG2A ligand, Qa-1b, manifested significantly greater pulmonary pathology upon CD8+ T cell-mediated clearance in influenza pneumonia. Furthermore, blockade of NKG2A ligation resulted in the enhancement of lung injury induced by CD8+ effector cell recognition of alveolar Ag in vivo in the absence of infectious virus. These data demonstrate that CD94/NKG2A transduces a biologically important signal in vivo to activated CD8+ T cells that limits immunopathology in severe influenza infection."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.1.25"xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/author | "Cantor H."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/author | "Homer R."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/author | "Enelow R.I."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/pages | "25-29"xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/title | "Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia."xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18096998 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18096998 |
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| http://purl.uniprot.org/uniprot/#_E9QAJ6-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_E0CZ14-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUJ9-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_A6H5Z4-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_A7VMS5-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
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| http://purl.uniprot.org/uniprot/#_E9Q3T9-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_P06339-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
| http://purl.uniprot.org/uniprot/#_Q31153-mappedCitation-18096998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18096998 |
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