| http://purl.uniprot.org/citations/18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18097054 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via a receptor complex, which contains IL-4Ralpha and IL-13Ralpha1. A third, high-affinity IL-13 receptor, IL-13Ralpha2, also exists. Although it was initially felt to be a decoy receptor, this has not been formally demonstrated and the role(s) of this receptor has recently become controversial. To define the role(s) of IL-13Ralpha2 in IL-13-induced pulmonary inflammation and remodeling, we compared the effects of lung-targeted transgenic IL-13 in mice with wild-type and null IL-13Ralpha2 loci. We also investigated the effect of IL-13Ralpha2 deficiency on the OVA-induced inflammatory response. In this study, we show that in the absence of IL-13Ralpha2, IL-13-induced pulmonary inflammation, mucus metaplasia, subepithelial fibrosis, and airway remodeling are significantly augmented. These changes were accompanied by increased expression and production of chemokines, proteases, mucin genes, and TGF-beta1. Similarly, an enhanced inflammatory response was observed in an OVA-induced phenotype. In contrast, disruption of IL-13Ralpha2 had no effect on the tissue effects of lung-targeted transgenic IL-4. Thus, IL-13Ralpha2 is a selective and powerful inhibitor of IL-13-induced inflammatory, remodeling, and physiologic responses in the murine lung."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.1.522"xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Hu B."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Oh S.Y."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Cohn L."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Grusby M.J."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Elias J.A."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/author | "Homer R.J."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/pages | "522-529"xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/title | "IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung."xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18097054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18097054 |
| http://purl.uniprot.org/citations/18097054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18097054 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097054 |
| http://purl.uniprot.org/uniprot/#_O88786-mappedCitation-18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097054 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097054 |
| http://purl.uniprot.org/uniprot/#_P20109-mappedCitation-18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097054 |
| http://purl.uniprot.org/uniprot/#_Q3UNK5-mappedCitation-18097054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18097054 |
| http://purl.uniprot.org/uniprot/P20109 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18097054 |