| http://purl.uniprot.org/citations/18157086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18157086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18157086 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the function of histone modifications across inducible genes in mammalian cells requires quantitative, comparative analysis of their fate during gene activation and identification of enzymes responsible. We produced high-resolution comparative maps of the distribution and dynamics of H3K4me3, H3K36me3, H3K79me2 and H3K9ac across c-fos and c-jun upon gene induction in murine fibroblasts. In unstimulated cells, continuous turnover of H3K9 acetylation occurs on all K4-trimethylated histone H3 tails; distribution of both modifications coincides across promoter and 5' part of the coding region. In contrast, K36- and K79-methylated H3 tails, which are not dynamically acetylated, are restricted to the coding regions of these genes. Upon stimulation, transcription-dependent increases in H3K4 and H3K36 trimethylation are seen across coding regions, peaking at 5' and 3' ends, respectively. Addressing molecular mechanisms involved, we find that Huntingtin-interacting protein HYPB/Setd2 is responsible for virtually all global and transcription-dependent H3K36 trimethylation, but not H3K36-mono- or dimethylation, in these cells. These studies reveal four distinct layers of histone modification across inducible mammalian genes and show that HYPB/Setd2 is responsible for H3K36 trimethylation throughout the mouse nucleus."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601967"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601967"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Clayton A.L."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Clayton A.L."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Edmunds J.W."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Edmunds J.W."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Mahadevan L.C."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/author | "Mahadevan L.C."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/pages | "406-420"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/pages | "406-420"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/title | "Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/title | "Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation."xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18157086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18157086 |
| http://purl.uniprot.org/citations/18157086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18157086 |
| http://purl.uniprot.org/citations/18157086 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18157086 |
| http://purl.uniprot.org/citations/18157086 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18157086 |