| http://purl.uniprot.org/citations/18158329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18158329 | http://www.w3.org/2000/01/rdf-schema#comment | "Directional cell movement in response to external chemical gradients requires establishment of front-rear asymmetry, which distinguishes an up-gradient protrusive leading edge, where Rac-induced F-actin polymerization takes place, and a down-gradient retractile tail (uropod in leukocytes), where RhoA-mediated actomyosin contraction occurs. The signals that govern this spatial and functional asymmetry are not entirely understood. We show that the human type I phosphatidylinositol 4-phosphate 5-kinase isoform beta (PIPKIbeta) has a role in organizing signaling at the cell rear. We found that PIPKIbeta polarized at the uropod of neutrophil-differentiated HL60 cells. PIPKIbeta localization was independent of its lipid kinase activity, but required the 83 C-terminal amino acids, which are not homologous to other PIPKI isoforms. The PIPKIbeta C terminus interacted with EBP50 (4.1-ezrin-radixin-moesin (ERM)-binding phosphoprotein 50), which enabled further interactions with ERM proteins and the Rho-GDP dissociation inhibitor (RhoGDI). Knockdown of PIPKIbeta with siRNA inhibited cell polarization and impaired cell directionality during dHL60 chemotaxis, suggesting a role for PIPKIbeta in these processes."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200705044"xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Merino E."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Albar J.P."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Merida I."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Martinez-A C."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Lacalle R.A."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Manes S."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/author | "Peregil R.M."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/pages | "1539-1553"xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/title | "Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement."xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/18158329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18158329 |
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