| http://purl.uniprot.org/citations/18160346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18160346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18160346 | http://www.w3.org/2000/01/rdf-schema#comment | "While endocytosis can regulate morphogen distribution, its precise role in shaping these gradients is unclear. Even more enigmatic is the role of retromer, a complex that shuttles proteins between endosomes and the Golgi apparatus, in Wnt gradient formation. Here we report that DPY-23, the C. elegans mu subunit of the clathrin adaptor AP-2 that mediates the endocytosis of membrane proteins, regulates Wnt function. dpy-23 mutants display Wnt phenotypes, including defects in neuronal migration, neuronal polarity, and asymmetric cell division. DPY-23 acts in Wnt-expressing cells to promote these processes. MIG-14, the C. elegans homolog of the Wnt-secretion factor Wntless, also acts in these cells to control Wnt function. In dpy-23 mutants, MIG-14 accumulates at or near the plasma membrane. By contrast, MIG-14 accumulates in intracellular compartments in retromer mutants. Based on our observations, we propose that intracellular trafficking of MIG-14 by AP-2 and retromer plays an important role in Wnt secretion."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.12.001"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.12.001"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Baum P.D."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Baum P.D."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Clark S.G."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Clark S.G."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Garriga G."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Pan C.L."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/author | "Pan C.L."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/pages | "132-139"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/pages | "132-139"xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/title | "C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless."xsd:string |
| http://purl.uniprot.org/citations/18160346 | http://purl.uniprot.org/core/title | "C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless."xsd:string |