| http://purl.uniprot.org/citations/18160398 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18160398 | http://www.w3.org/2000/01/rdf-schema#comment | "The p21-activated kinase-1 (PAK1) is best known for its role in the regulation of cytoskeletal and transcriptional signaling pathways. We show here in the microglia cell line Ra2 that PAK1 regulates NADPH oxidase (NOX-2) activity in a stimulus-specific manner. Thus, conditional expression of PAK1 dominant-positive mutants enhanced, whereas dominant-negative mutants inhibited, NADPH oxidase-mediated superoxide generation following formyl-methionyl-leucylphenylalanine or phorbol 12-myristate 13-acetate stimulation. Both Rac1 and the GTP exchange factor VAV1 were required as upstream signaling proteins in the formyl-methionyl-leucyl-phenylalanine-induced activation of endogenous PAK1. In contrast, PAK1 mutants had no effect on superoxide generation downstream of FcgammaR signaling during phagocytosis of IgG-immune complexes. We further present evidence that the effect of PAK1 on the respiratory burst is mediated through phosphorylation of p47(Phox), and we show that expression of a p47(Phox) (S303D/S304D/S320D) mutant, which mimics phosphorylation by PAK1, induced basal superoxide generation in vivo. In contrast PAK1 substrates LIMK-1 or RhoGDI are not likely to contribute to the PAK1 effect on NADPH oxidase activation. Collectively, our findings define a VAV1-Rac1-PAK1 signaling axis in mononuclear phagocytes regulating superoxide production in a stimulus-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708281200"xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Sawada M."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Bokoch G."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Rasmussen I."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Salmon P."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "van Deurs B."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Roepstorff K."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Cudre-Maroux C."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/author | "Vilhardt F."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/pages | "7983-7993"xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/title | "Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis."xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18160398 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18160398 |
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