| http://purl.uniprot.org/citations/18160711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18160711 | http://www.w3.org/2000/01/rdf-schema#comment | "Fission yeast cells survive loss of the telomerase catalytic subunit Trt1 (TERT) through recombination-based telomere maintenance or through chromosome circularization. Although trt1Delta survivors with linear chromosomes can be obtained, they often spontaneously circularize their chromosomes. Therefore, it was difficult to establish genetic requirements for telomerase-independent telomere maintenance. In contrast, when the telomere-binding protein Taz1 is also deleted, taz1Delta trt1Delta cells are able to stably maintain telomeres. Thus, taz1Delta trt1Delta cells can serve as a valuable tool in understanding the regulation of telomerase-independent telomere maintenance. In this study, we show that the checkpoint kinase Tel1 (ATM) and the DNA repair complex Rad32-Rad50-Nbs1 (MRN) are required for telomere maintenance in taz1Delta trt1Delta cells. Surprisingly, Rap1 is also essential for telomere maintenance in taz1Delta trt1Delta cells, even though recruitment of Rap1 to telomeres depends on Taz1. Expression of catalytically inactive Trt1 can efficiently inhibit recombination-based telomere maintenance, but the inhibition requires both Est1 and Ku70. While Est1 is essential for recruitment of Trt1 to telomeres, Ku70 is dispensable. Thus, we conclude that Taz1, TERT-Est1, and Ku70-Ku80 prevent telomere recombination, whereas MRN-Tel1 and Rap1 promote recombination-based telomere maintenance. Evolutionarily conserved proteins in higher eukaryotic cells might similarly contribute to telomere recombination."xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01614-07"xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/author | "Moser B.A."xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/author | "Subramanian L."xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/author | "Nakamura T.M."xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/pages | "1443-1455"xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/title | "Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast."xsd:string |
| http://purl.uniprot.org/citations/18160711 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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