| http://purl.uniprot.org/citations/18163389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18163389 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous linkage studies have identified chromosome 8q24 as a promising positional candidate region to search for bipolar disorder (BP) susceptibility genes. We, therefore, sought to identify BP susceptibility genes on chromosome 8q24 using a family-based association study of a dense panel of SNPs selected to tag the known common variation across the region of interest. A total of 1,458 SNPs across 16 Mb of 8q24 were examined in 3,512 subjects, 1,954 of whom were affected with BP, from 737 multiplex families. Single-locus tests were carried out with FBAT and Geno-PDT, and multi-locus test were carried out with HBAT and multi-locus Geno-PDT. None of the SNPs were associated with BP in the single-locus tests at a level that exceeded our threshold for study-wide significance (P < 3.00 x 10(-5)). However, there was consistent evidence at our threshold for the suggestive level (P < 7.00 x 10(-4)) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 (P = 3.00 x 10(-4)), with at least one copy of the "high risk" allele required at both genes for association with BP, consistent with a jointly dominant-dominant model of action. These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.b.30651"xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "McInnis M.G."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Burmeister M."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Gopalakrishnan S."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Avramopoulos D."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Qin Z.S."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Willour V.L."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Potash J.B."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Miao K."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Zandi P.P."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Zollner S."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "Depaulo J.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/author | "McEachin R."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/name | "Am J Med Genet B Neuropsychiatr Genet"xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/pages | "612-618"xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/title | "Family-based SNP association study on 8q24 in bipolar disorder."xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://purl.uniprot.org/core/volume | "147B"xsd:string |
| http://purl.uniprot.org/citations/18163389 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18163389 |
| http://purl.uniprot.org/citations/18163389 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18163389 |
| http://purl.uniprot.org/uniprot/#_A0A0K0K1K3-mappedCitation-18163389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18163389 |
| http://purl.uniprot.org/uniprot/#_P40145-mappedCitation-18163389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18163389 |