| http://purl.uniprot.org/citations/18163421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18163421 | http://www.w3.org/2000/01/rdf-schema#comment | "Late-onset Alzheimer's disease (LOAD) is a genetically complex neurodegenerative disorder. Currently, only the epsilon4 allele of the Apolipoprotein E gene has been identified unequivocally as a genetic susceptibility factor for LOAD. Others remain to be found. In 2002 we observed genome-wide significant evidence of linkage to a region on chromosome 10q11.23-q21.3 [Myers et al. (2002) Am J Med Genet 114:235-244]. Our objective in this study was to test every gene within the maximum LOD-1 linkage region, for association with LOAD. We obtained results for 528 SNPs from 67 genes, with an average density of 1 SNP every 10 kb within the genes. We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls. These results would not survive correction for multiple testing but warrant attempts at confirmation in independent samples."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.b.30670"xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Williams J."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Rubinsztein D.C."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Powell J."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Gill M."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Owen M.J."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Abraham R."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Hamilton G."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Lovestone S."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Harold D."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Moskvina V."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Hollingworth P."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Morgan A.R."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Turic D."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Brayne C."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "O'Donovan M."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Lawlor B."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Lynch A."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/author | "Jehu L."xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/name | "Am J Med Genet B Neuropsychiatr Genet"xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/pages | "727-731"xsd:string |
| http://purl.uniprot.org/citations/18163421 | http://purl.uniprot.org/core/title | "Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease."xsd:string |