| http://purl.uniprot.org/citations/18163884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18163884 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine K-cells in response to nutrient absorption. This study has utilised numerous well-characterised dipeptidyl peptidase IV-resistant GIP analogues to evaluate the glucagonotropic actions of GIP in Wistar rats and isolated rat islets. Intraperitoneal administration of GIP analogues (25 nmol/kg body weight) in combination with glucose had no effect on circulating glucagon concentrations compared to controls in Wistar rats. However, plasma glucose concentrations were significantly (p<0.05 to p<0.001) lowered by the GIP-receptor agonists, N-AcGIP, GIP(Lys37)PAL and N-AcGIP(Lys37)PAL. The GIP antagonist, (Pro3)GIP, caused a significant (p<0.05) reduction in glucagon levels following concurrent administration with saline in Wistar rats. In isolated rat islets native GIP induced a significant (p<0.01) enhancement of glucagon release at basal glucose concentrations, which was completely annulled by (Pro3)GIP. Furthermore, glucagon release in the presence of GLP-1, GIP(Lys37)PAL, N-AcGIP(Lys37)PAL and (Pro3)GIP was significantly (p<0.05 to p<0.001) decreased compared to native GIP in isolated rat islets. These data indicate a modest effect of GIP on glucagon secretion from isolated rat islets, which was not observed in vivo. However, the GIP agonists N-AcGIP, GIP(Lys37)PAL and N-AcGIP(Lys37)PAL had no effect on glucagon release demonstrating an improved therapeutic potential for the treatment of type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.org/dc/terms/identifier | "doi:10.1515/bc.2008.019"xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/author | "Irwin N."xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/author | "Flatt P.R."xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/author | "Cassidy R.S."xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/name | "Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/pages | "189-193"xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/title | "Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets."xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://purl.uniprot.org/core/volume | "389"xsd:string |
| http://purl.uniprot.org/citations/18163884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18163884 |
| http://purl.uniprot.org/citations/18163884 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18163884 |
| http://purl.uniprot.org/uniprot/#_A6HIC2-mappedCitation-18163884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18163884 |
| http://purl.uniprot.org/uniprot/#_A6HIC4-mappedCitation-18163884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18163884 |
| http://purl.uniprot.org/uniprot/#_Q06145-mappedCitation-18163884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18163884 |
| http://purl.uniprot.org/uniprot/A6HIC2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18163884 |
| http://purl.uniprot.org/uniprot/A6HIC4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18163884 |
| http://purl.uniprot.org/uniprot/Q06145 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18163884 |