| http://purl.uniprot.org/citations/18174329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18174329 | http://www.w3.org/2000/01/rdf-schema#comment | "In recent years, it has become clear that, in addition to conventional anterograde transmission, signaling in neural circuits can occur in a retrograde manner. This suggests the additional possibility that postsynaptic release of neurotransmitter might be able to act in an autocrine fashion. Here, we show that brief depolarization of a cerebellar Purkinje cell triggers a slow inward current. This depolarization-induced slow current (DISC) is attenuated by antagonists of mGluR1 or TRP channels. DISC is eliminated by a mixture of voltage-sensitive Ca2+ channel blockers and is mimicked by a brief climbing fiber burst. DISC is attenuated by an inhibitor of vesicular glutamate transporters or of vesicular fusion. These data suggest that Ca2+-dependent postsynaptic fusion of glutamate-loaded vesicles evokes a slow inward current produced by activation of postsynaptic mGluR1, thereby constituting a useful form of feedback regulation."xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709407105"xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/author | "Shin J.H."xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/author | "Linden D.J."xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/pages | "746-750"xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/title | "Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells."xsd:string |
| http://purl.uniprot.org/citations/18174329 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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