| http://purl.uniprot.org/citations/18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18174467 | http://www.w3.org/2000/01/rdf-schema#comment | "Circulating levels of high-density lipoprotein (HDL) cholesterol are inversely related to the risk of cardiovascular disease, and HDL and the HDL receptor scavenger receptor class B type I (SR-BI) initiate signaling in endothelium through src that promotes endothelial NO synthase activity and cell migration. Such signaling requires the C-terminal PDZ-interacting domain of SR-BI. Here we show that the PDZ domain-containing protein PDZK1 is expressed in endothelium and required for HDL activation of endothelial NO synthase and cell migration; in contrast, endothelial cell responses to other stimuli, including vascular endothelial growth factor, are PDZK1-independent. Coimmunoprecipitation experiments reveal that Src interacts with SR-BI, and this process is PDZK1-independent. PDZK1 also does not regulate SR-BI abundance or plasma membrane localization in endothelium or HDL binding or cholesterol efflux. Alternatively, PDZK1 is required for HDL/SR-BI to induce Src phosphorylation. Paralleling the in vitro findings, carotid artery reendothelialization following perivascular electric injury is absent in PDZK1-/-mice, and this phenotype persists in PDZK1-/-mice with genetic reconstitution of PDZK1 expression in liver, where PDZK1 modifies SR-BI abundance. Thus, PDZK1 is uniquely required for HDL/SR-BI signaling in endothelium, and through these mechanisms, it is critically involved in the maintenance of endothelial monolayer integrity."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.org/dc/terms/identifier | "doi:10.1161/circresaha.107.159079"xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Silver D.L."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Mineo C."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Shaul P.W."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Chambliss K.L."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Yuhanna I.S."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Seetharam D."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Saddar S."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/author | "Longoria C."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/pages | "480-487"xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/title | "The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity."xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/18174467 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18174467 |
| http://purl.uniprot.org/citations/18174467 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18174467 |
| http://purl.uniprot.org/uniprot/#_D3YW13-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |
| http://purl.uniprot.org/uniprot/#_D3Z114-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |
| http://purl.uniprot.org/uniprot/#_D3Z5U8-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1V0-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |
| http://purl.uniprot.org/uniprot/#_F7C5U2-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |
| http://purl.uniprot.org/uniprot/#_D3YZS9-mappedCitation-18174467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18174467 |