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http://purl.uniprot.org/citations/18175566http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18175566http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the expression of caspase-6 in rat skin contusion and its surrounding areas during repairment.

Methods

Immunohistochemical SP method and Western blot technique were used to study the expression and activation of caspase-6 in rat skin contusion and its surrounding areas.

Results

Weak expression of caspase-6 was detected in cytoplasms of polymorphonuchear cells (PMNs) infiltrated in the injured area at 3 hours post-contusion. The ratio of the caspase-6 positive cells was low (25.78 +/-1.38)%. The expression of caspase-6 was increased prominently (47.70 +/-5.14)% at 12 hours post-contusion. Almost all of the PMNs, mononuclear cells (MNCs) and fibroblastic cells (FBCs) were caspase-6 positive with both cytoplasm and nucleus staining (54.58 +/-5.64)% on post-contusion day 3. The expression of caspase-6 decreased gradually thereafter. The expression of the 34-kDa pro-caspase-6 was detected by Western blot in both control and the post-contusion groups with time dependent dynamics.

Conclusion

These results suggest that caspase-6 may play a major role in trauma-induced inflammatory response. Since caspase-6 shows a timely dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat, it may be used as a marker for the contusion age determination,"xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/author"Peng X."xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/author"Wang Q."xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/author"Guan D.W."xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/name"Fa Yi Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/pages"325-327"xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/title"[A study on the time-dependent expression of caspase-6 during repair of skin contusion in rats]."xsd:string
http://purl.uniprot.org/citations/18175566http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/18175566http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18175566
http://purl.uniprot.org/citations/18175566http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18175566
http://purl.uniprot.org/uniprot/O35397#attribution-BE13526CEED14FCC9B858029AAF30BD9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/#_A6HVQ6-mappedCitation-18175566http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/#_O35397-mappedCitation-18175566http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/#_F6Q5I5-mappedCitation-18175566http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/#_Q6AZ23-mappedCitation-18175566http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/Q6AZ23http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/A6HVQ6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/O35397http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18175566
http://purl.uniprot.org/uniprot/F6Q5I5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/18175566