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http://purl.uniprot.org/citations/18176969http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18176969http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro.

Methods

Supernatant resistin was measured during differentiation of 3T3-L1 preadipocytes. L6 rat myoblasts and hepatoma cell line H4IIE were used to confirm the cellular function of resistin. Diet-induced obese rats were used as an insulin resistance model to study the relationship of resistin with insulin resistance.

Results

Resistin expression and secretion were enhanced during differentiation 3T3-L1 preadipocytes. This cellular differentiation stimulated resistin expression and secretion, but was suppressed by insulin. Resistin also induced insulin resistance in H4IIE hepatocytes and L6 myoblasts. In diet-induced obese rats, serum resistin levels were negatively correlated with insulin sensitivity, but not with serum insulin.

Conclusion

Insulin can inhibit resistin expression and secretion in vitro, but insulin is not a major regulator of resistin in vivo. Fat tissue mass affects insulin sensitivity by altering the expression and secretion of resistin."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.org/dc/terms/identifier"doi:10.3748/wjg.14.95"xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Guo M."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Liu F."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Qiu J."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Wang B."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Zhang M."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Chen R.H."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Zhang C.M."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Pan X.Q."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Fan H.Q."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Fei L."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Guo X.R."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/author"Gu N."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/pages"95-100"xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/title"A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance."xsd:string
http://purl.uniprot.org/citations/18176969http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/18176969http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18176969
http://purl.uniprot.org/citations/18176969http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18176969
http://purl.uniprot.org/uniprot/#_Q3V2F6-mappedCitation-18176969http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18176969
http://purl.uniprot.org/uniprot/#_Q99P87-mappedCitation-18176969http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18176969
http://purl.uniprot.org/uniprot/#_Q5BMX4-mappedCitation-18176969http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18176969
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