| http://purl.uniprot.org/citations/18178551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178551 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factors belonging to the NF-kappaB family regulate inflammation by inducing pro-inflammatory molecules (e.g. interleukin (IL)-8) in response to cytokines (e.g. tumor necrosis factor (TNF) alpha, IL-1) or other stimuli. Several negative regulators of NF-kappaB, including the ubiquitin-editing enzyme A20, participate in the resolution of inflammatory responses. We report that Cezanne, a member of the A20 family of the deubiquitinating cysteine proteases, can be induced by TNFalpha in cultured cells. Silencing of endogenous Cezanne using small interfering RNA led to elevated NF-kappaB luciferase reporter gene activity and enhanced expression of IL-8 transcripts in TNFalpha-treated cells. Thus we conclude that endogenous Cezanne can attenuate NF-kappaB activation and the induction of pro-inflammatory transcripts in response to TNF receptor (TNFR) signaling. Overexpression studies revealed that Cezanne suppressed NF-kappaB nuclear translocation and transcriptional activity by targeting the TNFR signaling pathway at the level of the IkappaB kinase complex or upstream from it. These effects were not observed in a form of Cezanne that was mutated at the catalytic cysteine residue (Cys209), indicating that the deubiquitinating activity of Cezanne is essential for NF-kappaB regulation. Finally, we demonstrate that Cezanne can be recruited to activated TNFRs where it suppresses the build-up of polyubiquitinated RIP1 signal adapter proteins. Thus we conclude that Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708690200"xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708690200"xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Dean J.L."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Dean J.L."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Rawlinson L."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Rawlinson L."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Haskard D.O."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Haskard D.O."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Chaudhury H."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Chaudhury H."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Enesa K."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Enesa K."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Evans P.C."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Evans P.C."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Luong le A."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Luong le A."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Mason J.C."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Mason J.C."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Zakkar M."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/author | "Zakkar M."xsd:string |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178551 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |