| http://purl.uniprot.org/citations/18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178617 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies have shown that alpha-synuclein (alpha-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129. We used recombinant Adeno-associated virus (rAAV) to overexpress human wild-type (wt) alpha-syn and two human alpha-syn mutants with site-directed replacement of Ser-129 to alanine (S129A) or to aspartate (S129D) in the nigrostriatal tract of the rat to investigate the effect of Ser-129 phosphorylation state on dopaminergic neuron pathology. Rats were injected with rAAV2/5 vectors in the substantia nigra pars compacta (SNc) on one side of the brain; the other side remained as a nontransduced control. The level of human wt or mutant alpha-syn expressed on the injected side was about four times the endogenous rat alpha-syn. There was a significant reduction of dopaminergic neurons in the SNc and dopamine (DA) and tyrosine hydroxylase (TH) levels in the striatum of all S129A-treated rats as early as 4 wk postinjection. Nigral DA pathology occurred more slowly in the wt-injected animals, but by 26 wk the wt alpha-syn group lost nigral TH neurons equivalent to the mutated S129A group at 8 wk. In stark contrast, we did not observe any pathological changes in S129D-treated animals. Therefore, the nonphosphorylated form of S129 exacerbates alpha-syn-induced nigral pathology, whereas Ser-129 phosphorylation eliminates alpha-syn-induced nigrostriatal degeneration. This suggests possible new therapeutic targets for Parkinson Disease."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0711053105"xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Muzyczka N."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Mandel R.J."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Gorbatyuk O.S."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Kondrikova G."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Manfredsson F.P."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/author | "Sullivan L.F."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/pages | "763-768"xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/title | "The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease."xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18178617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18178617 |
| http://purl.uniprot.org/citations/18178617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18178617 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTN7-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HU10-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_A6KF04-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_A6KF07-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_H6UYS7-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_H6UYS0-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |
| http://purl.uniprot.org/uniprot/#_H6UYS5-mappedCitation-18178617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178617 |