| http://purl.uniprot.org/citations/18178622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178622 | http://www.w3.org/2000/01/rdf-schema#comment | "Allosteric signaling in proteins requires long-range communication mediated by highly conserved residues, often triggered by ligand binding. In this article, we map the allosteric network in the catalytic subunit of protein kinase A using NMR spectroscopy. We show that positive allosteric cooperativity is generated by nucleotide and substrate binding during the transitions through the major conformational states: apo, intermediate, and closed. The allosteric network is disrupted by a single site mutation (Y204A), which also decouples the cooperativity of ligand binding. Because protein kinase A is the prototype for the entire kinome, these findings may serve as a paradigm for describing long-range coupling in other protein kinases."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709214104"xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0709214104"xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Masterson L.R."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Masterson L.R."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Veglia G."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Veglia G."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Mascioni A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Mascioni A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Traaseth N.J."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/author | "Traaseth N.J."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/pages | "506-511"xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/pages | "506-511"xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/title | "Allosteric cooperativity in protein kinase A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/title | "Allosteric cooperativity in protein kinase A."xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18178622 | http://purl.uniprot.org/core/volume | "105"xsd:string |