| http://purl.uniprot.org/citations/18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178624 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we report the effects of loss of the Toll-like receptor-associated signaling adaptor myeloid-differentiation factor 88 (MyD88) on tumor induction in two distinct mouse models of carcinogenesis. The 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin papilloma model depends on proinflammatory processes, whereas the 3'-methylcholanthrene (MCA) induction of fibrosarcoma has been used by tumor immunologists to illustrate innate and adaptive immune surveillance of cancer. When exposed to a combination of DMBA/TPA, mice lacking MyD88 formed fewer skin papillomas than genetically matched WT controls treated in a similar manner. Unexpectedly, however, fewer MyD88-/-mice formed sarcomas than WT controls when exposed to MCA. In contrast, MyD88-deficient mice did not show a defective ability to reject highly immunogenic transplanted tumors, including MCA sarcomas. Despite the reported role of TNF in chronic inflammation, TNF-deficient mice were significantly more susceptible to MCA-induced sarcoma than WT mice. Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0708594105"xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Silva A."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Schreiber R.D."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Swann J.B."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Sharkey J."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/author | "Vesely M.D."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/pages | "652-656"xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/title | "Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18178624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18178624 |
| http://purl.uniprot.org/citations/18178624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18178624 |
| http://purl.uniprot.org/uniprot/#_A0A0U5CJG6-mappedCitation-18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178624 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178624 |
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| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178624 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178624 |
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| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-18178624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178624 |