| http://purl.uniprot.org/citations/18178771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178771 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178771 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA damage tolerance (DDT) in budding yeast requires Lys-63-linked polyubiquitination of the proliferating cell nuclear antigen. The ubiquitin-conjugating enzyme Ubc13 and the Ubc enzyme variant (Uev) methyl methanesulfonate2 (Mms2) are required for this process. Mms2 homologs have been found in all eukaryotic genomes examined; however, their roles in multicellular eukaryotes have not been elucidated. We report the isolation and characterization of four UEV1 genes from Arabidopsis thaliana. All four Uev1 proteins can form a stable complex with At Ubc13 or with Ubc13 from yeast or human and can promote Ubc13-mediated Lys-63 polyubiquitination. All four Uev1 proteins can replace yeast MMS2 DDT functions in vivo. Although these genes are ubiquitously expressed in most tissues, UEV1D appears to express at a much higher level in germinating seeds and in pollen. We obtained and characterized two uev1d null mutant T-DNA insertion lines. Compared with wild-type plants, seeds from uev1d null plants germinated poorly when treated with a DNA-damaging agent. Those that germinated grew slower, and the majority ceased growth within 2 weeks. Pollen from uev1d plants also displayed a moderate but significant decrease in germination in the presence of DNA damage. This report links Ubc13-Uev with functions in DNA damage response in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.107.051862"xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.107.051862"xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Lai X."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Lai X."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Xiao W."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Xiao W."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Wen R."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Wen R."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Pastushok L."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Pastushok L."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Pelzer L."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Pelzer L."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Torres-Acosta J.A."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/author | "Torres-Acosta J.A."xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/name | "Plant Cell"xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/name | "Plant Cell"xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/pages | "213-227"xsd:string |
| http://purl.uniprot.org/citations/18178771 | http://purl.uniprot.org/core/pages | "213-227"xsd:string |