| http://purl.uniprot.org/citations/18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18178823 | http://www.w3.org/2000/01/rdf-schema#comment | "Th1 cells have different capacities to develop into memory cells based on their production of IFN-gamma. In this study, the mechanism by which a homogenous population of IFN-gamma-producing CD4 T cells was eliminated in vivo was assessed. When such cells were transferred into naive mice and activated with Ag, a striking decrease in the frequency of cells in the spleen and lung was observed. However, administration of neutralizing anti-IFN-gamma Ab at the time of Ag challenge largely prevented the elimination of such cells. To determine whether IFN-gamma was mediating its effects directly and/or indirectly, the ability of IFN-gamma to effectively signal in such cells was assessed in vitro. Indeed, there was reduced phosphorylation of STAT1 in response to IFN-gamma as well as markedly reduced expression of the IFN-gammaR beta-chain. Furthermore, transfer of such cells into IFN-gammaR-deficient mice limited their death following activation with Ag. Together, these data suggest that IFN-gamma acts in a paracrine manner to mediate the death of activated IFN-gamma-producing Th1 cells. In contrast to Ag stimulation, administration of CpG alone resulted in the elimination of Th1 cells in IFN-gammaR-/-mice. These results show that in response to Ag stimulation, the death of IFN-gamma-producing effector Th1 cells is controlled in an IFN-gamma-dependent manner, whereas in response to innate activation, the death of IFN-gamma-producing Th1 cells can occur through an IFN-gamma-independent pathway. Collectively, these data show the multiple mechanisms by which Th1 effector cells are efficiently eliminated in vivo."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.2.842"xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Singh B."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Seder R.A."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Wu C.Y."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "O'Shea J.J."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Watford W.T."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Douek D.C."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Paley M.A."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Hill B.J."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Foulds K.E."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/author | "Rotte M.J."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/pages | "842-849"xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/title | "IFN-gamma mediates the death of Th1 cells in a paracrine manner."xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18178823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18178823 |
| http://purl.uniprot.org/citations/18178823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18178823 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178823 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178823 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178823 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178823 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-18178823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18178823 |