| http://purl.uniprot.org/citations/18180292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18180292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18180292 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms by which the AP-1 transcription factor c-Jun exerts its biological functions are not clearly understood. In addition to its well established role in transcriptional regulation of gene expression, several reports have suggested that c-Jun may also regulate cell behavior by non-transcriptional mechanisms. Here, we report that small interfering RNA-mediated depletion of c-Jun from mammalian cells results in inhibition of 28 S and 18 S rRNA accumulation. Moreover, we show that c-Jun depletion results in partial translocation of RNA helicase DDX21, implicated in rRNA processing, from the nucleolus to the nucleoplasm. We demonstrate that DDX21 translocation is rescued by exogenous c-Jun expression and that c-Jun depletion inhibits rRNA binding of DDX21. Furthermore, the direct interaction between c-Jun and DDX21 regulates nucleolar localization of DDX21. These results demonstrate that in addition to its transcriptional effects, c-Jun regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21. Thus, our results demonstrate a nucleolar mechanism through which c-Jun can regulate cell behavior. Moreover, these results suggest that the phenotypes observed previously in c-Jun-depleted mouse models and cell lines could be partly due to the effects of c-Jun on rRNA processing."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m709613200"xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m709613200"xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Westermarck J."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Westermarck J."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Nymalm Y."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Nymalm Y."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Salminen T.A."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Salminen T.A."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Johansson H."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Johansson H."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Valdez B.C."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Valdez B.C."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Black E."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Black E."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Gillespie D."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Gillespie D."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Langel U."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Langel U."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Holm T."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Holm T."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Kallio M."xsd:string |
| http://purl.uniprot.org/citations/18180292 | http://purl.uniprot.org/core/author | "Kallio M."xsd:string |