| http://purl.uniprot.org/citations/18183619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18183619 | http://www.w3.org/2000/01/rdf-schema#comment | "We used electrophoretic mobility shift assays to investigate the effects of cobalamin (Cbl) deficiency on the levels of activated nuclear factor-kappa B (NF-kappaB) in the spinal cords (SCs) and livers of rats made Cbl-deficient (Cbl-D) by total gastrectomy or a Cbl-D diet. We chose the SC and liver because they are severely or scarcely affected, respectively, by Cbl deficiency in terms of histological damage. We found permanently increased NF-kappaB levels (particularly the p50 and p65 subunits) in the SCs and livers of both types of Cbl-D rats, and Western blot analysis demonstrated increased p65 levels. NF-kappaB and p65 protein levels normalized when the totally gastrectomized (TGX) rats were treated with Cbl replacement. As we have previously demonstrated that Cbl deficiency increases tumor necrosis factor (TNF)-alpha and nerve growth factor (NGF) levels in the SC (each of which is a known NF-kappaB activator), we redetermined NF-kappaB levels in the SCs and livers of TGX rats treated with anti-TNF-alpha or anti-NGF antibodies and found that NF-kappaB levels normalized in both tissues after either treatment. These results demonstrate that: (1) Cbl physiologically and indirectly down-regulates NF-kappaB levels in rat SC and liver, and (2) NF-kappaB is an important signaling molecule after Cbl deficiency injury."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.21599"xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Tredici G."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Tacchini L."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Mutti E."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Scalabrino G."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Veber D."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/author | "Gammella E."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/pages | "1380-1387"xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/title | "Indirect down-regulation of nuclear NF-kappaB levels by cobalamin in the spinal cord and liver of the rat."xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/18183619 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18183619 |
| http://purl.uniprot.org/citations/18183619 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18183619 |
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