| http://purl.uniprot.org/citations/18184562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18184562 | http://www.w3.org/2000/01/rdf-schema#comment | "Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expansion of a translated CAG repeat in the N terminus of the huntingtin (htt) protein. Here we describe the generation and characterization of a full-length HD Drosophila model to reveal a previously unknown disease mechanism that occurs early in the course of pathogenesis, before expanded htt is imported into the nucleus in detectable amounts. We find that expanded full-length htt (128Qhtt(FL)) leads to behavioral, neurodegenerative, and electrophysiological phenotypes. These phenotypes are caused by a Ca2+-dependent increase in neurotransmitter release efficiency in 128Qhtt(FL) animals. Partial loss of function in synaptic transmission (syntaxin, Snap, Rop) and voltage-gated Ca2+ channel genes suppresses both the electrophysiological and the neurodegenerative phenotypes. Thus, our data indicate that increased neurotransmission is at the root of neuronal degeneration caused by expanded full-length htt during early stages of pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.11.025"xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Bellen H.J."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Verstreken P."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Botas J."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Hughes R.E."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Romero E."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Cha G.H."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/author | "Ly C.V."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/pages | "27-40"xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/title | "Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/18184562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18184562 |
| http://purl.uniprot.org/citations/18184562 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18184562 |
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| http://purl.uniprot.org/uniprot/#_A0A126GV04-mappedCitation-18184562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18184562 |
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| http://purl.uniprot.org/uniprot/#_A0A4D6K2Y3-mappedCitation-18184562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18184562 |
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| http://purl.uniprot.org/uniprot/#_P21521-mappedCitation-18184562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18184562 |
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