| http://purl.uniprot.org/citations/18184567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18184567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18184567 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal activity augments maturation of mushroom-shaped spines to form excitatory synapses, thereby strengthening synaptic transmission. We have delineated a Ca(2+)-signaling pathway downstream of the NMDA receptor that stimulates calmodulin-dependent kinase kinase (CaMKK) and CaMKI to promote formation of spines and synapses in hippocampal neurons. CaMKK and CaMKI form a multiprotein signaling complex with the guanine nucleotide exchange factor (GEF) betaPIX and GIT1 that is localized in spines. CaMKI-mediated phosphorylation of Ser516 in betaPIX enhances its GEF activity, resulting in activation of Rac1, an established enhancer of spinogenesis. Suppression of CaMKK or CaMKI by pharmacological inhibitors, dominant-negative (dn) constructs and siRNAs, as well as expression of the betaPIX Ser516Ala mutant, decreases spine formation and mEPSC frequency. Constitutively-active Pak1, a downstream effector of Rac1, rescues spine inhibition by dnCaMKI or betaPIX S516A. This activity-dependent signaling pathway can promote synapse formation during neuronal development and in structural plasticity."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.11.016"xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.11.016"xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Hoshi N."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Hoshi N."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Nozaki N."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Nozaki N."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Davare M."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Davare M."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Fortin D."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Fortin D."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Saneyoshi T."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Saneyoshi T."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Soderling T.R."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Soderling T.R."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Wayman G."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/author | "Wayman G."xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/18184567 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |