| http://purl.uniprot.org/citations/18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18188456 | http://www.w3.org/2000/01/rdf-schema#comment | "Eosinophilic inflammation is a cornerstone of chronic asthma that often culminates in subepithelial fibrosis with variable airway obstruction. Pulmonary eosinophils (Eos) are a predominant source of TGF-beta1, which drives fibroblast proliferation and extracellular matrix deposition. We investigated the regulation of TGF-beta1 and show here that the peptidyl-prolyl isomerase (PPIase) Pin1 promoted the stability of TGF-beta1 mRNA in human Eos. In addition, Pin1 regulated cytokine production by both in vitro and in vivo activated human Eos. We found that Pin1 interacted with both PKC-alpha and protein phosphatase 2A, which together control Pin1 isomerase activity. Pharmacologic blockade of Pin1 in a rat asthma model selectively reduced eosinophilic pulmonary inflammation, TGF-beta1 and collagen expression, and airway remodeling. Furthermore, chronically challenged Pin1(-/-) mice showed reduced peribronchiolar collagen deposition compared with wild-type controls. These data suggest that pharmacologic suppression of Pin1 may be a novel therapeutic option to prevent airway fibrosis in individuals with chronic asthma."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci32789"xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Sandor M."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Esnault S."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Shen Z.J."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Malter J.S."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Rosenthal L.A."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Szakaly R.J."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Sorkness R.L."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/author | "Westmark P.R."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/pages | "479-490"xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/title | "Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis."xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/18188456 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18188456 |
| http://purl.uniprot.org/citations/18188456 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18188456 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AJH7-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GJ67-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AB19-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_B3KUM4-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_B0BNL2-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_F7EW79-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |
| http://purl.uniprot.org/uniprot/#_Q13526-mappedCitation-18188456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18188456 |