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http://purl.uniprot.org/citations/18192296http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18192296http://www.w3.org/2000/01/rdf-schema#comment"

Background

Polycystic ovary syndrome (PCOS) may be programmed in utero by androgen excess. Our aim was to examine the role of the sex hormone-binding globulin (SHBG) and androgen receptor (AR) gene polymorphisms, in the phenotypic expression of PCOS.

Methods

A cohort of 180 women with PCOS and 168 healthy women of reproductive age were investigated. BMI was recorded and the hormonal profile was determined on Day 3-5 of menstrual cycle. DNA was extracted from peripheral blood leucocytes and the SHBG(TAAAA)n and AR(CAG)n polymorphisms were genotyped by PCR.

Results

Genotype analysis revealed six SHBG(TAAAA)n alleles with 6-11 repeats and 19 AR(CAG)n alleles with 6-32 repeats, present in both PCOS and control women. Long SHBG(TAAAA)n alleles (>8 repeats) were at greater frequency in PCOS than normal women (P = 0.001), whereas short AR(CAG)n alleles (ConclusionsThe presence of long SHBG(TAAAA)n alleles is associated with increased risk for PCOS and in combination with short AR(CAG)n alleles may influence the hyperandrogenic phenotype of PCOS. This combined genotype may contribute to 'fetal programming' of PCOS."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.org/dc/terms/identifier"doi:10.1093/humrep/dem382"xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Tsatsoulis A."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Kolios G."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Georgiou I."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Xita N."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Lazaros L."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/author"Psofaki V."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/name"Hum Reprod"xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/pages"693-698"xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/title"The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome."xsd:string
http://purl.uniprot.org/citations/18192296http://purl.uniprot.org/core/volume"23"xsd:string
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