| http://purl.uniprot.org/citations/18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18197414 | http://www.w3.org/2000/01/rdf-schema#comment | "As the only barrier between blood and bile compartments hepatocellular tight junctions play a crucial role in cholestasis-induced increase of biliary permeability. The molecular basis of this reversible defect is not known. We, therefore, examined expression, phosphorylation, distribution and colocalization of the junctional proteins occludin, claudin-1-3, ZO-1 and ZO-2 in rats after bile duct ligation and release of ligation. In control rats, claudin-1 and ZO-2 displayed a lobular gradient with highest expression levels in periportal cells, whereas claudin-2 showed a reciprocal distribution. Other proteins were evenly expressed in the liver lobule. Ligation resulted in upregulation of ZO-2 (2.7-fold), ZO-1 (1.4-fold) and occludin (1.2-fold) but not of claudins. Only ZO-2 showed increased phosphorylation. Distribution patterns were unchanged except for a strong accumulation of ZO-2 in perivenous hepatocytes. Colocalization analysis demonstrated that perivenous ZO-2 was the only protein examined revealing strongly increased overlap with occludin and ZO-1, whereas claudins and other proteins displayed a decrease. All changes were partially reversed by release of ligation. We conclude that differential expression of claudin-1-2 and ZO-2 has functional implications for bile formation. The moderately increased ZO-1 and occludin levels account for the known elongation of tight junction strands. The highly increased expression and changed distribution of ZO-2 suggests that ZO-1 is partly substituted by ZO-2, an alteration possibly causing impaired barrier function."xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00418-007-0374-7"xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/author | "Landmann L."xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/author | "Maly I.P."xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/name | "Histochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/pages | "289-299"xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/title | "Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin."xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/18197414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18197414 |
| http://purl.uniprot.org/citations/18197414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18197414 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K2P5-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_D4A386-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_P70625-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GLX8-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A0A8L2R644-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A6HLS9-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A6I0Q0-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A6I0Q1-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AFQ2-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_F1M4A0-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/#_Q3ZB99-mappedCitation-18197414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/A6HLS9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18197414 |
| http://purl.uniprot.org/uniprot/D4A386 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18197414 |