| http://purl.uniprot.org/citations/18202122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202122 | http://www.w3.org/2000/01/rdf-schema#comment | "The physiological changes that sperm undergo in the female reproductive tract rendering them fertilization-competent constitute the phenomenon of capacitation. Cholesterol efflux from the sperm surface and protein kinase A (PKA)-dependent phosphorylation play major regulatory roles in capacitation, but the link between these two phenomena is unknown. We report that apolipoprotein A-I binding protein (AI-BP) is phosphorylated downstream to PKA activation, localizes to both sperm head and tail domains, and is released from the sperm into the media during in vitro capacitation. AI-BP interacts with apolipoprotein A-I, the component of high-density lipoprotein involved in cholesterol transport. The crystal structure demonstrates that the subunit of the AI-BP homodimer has a Rossmann-like fold. The protein surface has a large two compartment cavity lined with conserved residues. This cavity is likely to constitute an active site, suggesting that AI-BP functions as an enzyme. The presence of AI-BP in sperm, its phosphorylation by PKA, and its release during capacitation suggest that AI-BP plays an important role in capacitation possibly providing a link between protein phosphorylation and cholesterol efflux."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2007-0582"xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2007-0582"xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Minor W."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Minor W."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Shumilin I.A."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Shumilin I.A."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Chertihin O."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Chertihin O."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Herr J.C."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Herr J.C."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Jha K.N."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Jha K.N."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Schmitz G."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Schmitz G."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Visconti P.E."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Visconti P.E."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Flickinger C.J."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Flickinger C.J."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Digilio L.C."xsd:string |
| http://purl.uniprot.org/citations/18202122 | http://purl.uniprot.org/core/author | "Digilio L.C."xsd:string |