| http://purl.uniprot.org/citations/18202225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202225 | http://www.w3.org/2000/01/rdf-schema#comment | "In human monocytes, tumor necrosis factor (TNF) induces a proinflammatory response. In NF-kappaB-inhibited monocytes, TNF stimulates cell death/apoptosis. In the present study, we analyzed the response of acute myeloid leukemia (AML) cells to TNF stimulation in conjunction with NF-kappaB inhibition. In all AML-derived cells tested, NF-kappaB-inhibited cells were resistant to TNF-induced apoptosis. Further investigation revealed that the cytoprotective gene heme oxygenase-1 (HO-1) was induced in NF-kappaB-inhibited AML cells in response to TNF stimulation, and HO-1 was responsible for the resistance of AML cells to the cytotoxic actions of TNF. Moreover, after transfection with HO-1 siRNA, the resistance to TNF-induced cell death signals of AML cells was removed. The HO-1 promoter region contains antioxidant-response elements that can bind the transcription factor NF-E2-related factor 2 (Nrf2). We further demonstrated that Nrf2 was activated by TNF under NF-kappaB-inhibited conditions, to play the major role in up-regulating HO-1 expression and ultimately the fate of AML cells. These results demonstrate a novel mechanism by which TNF-induced cell death is inhibited in AML cells through the induction of HO-1, via Nrf2 activation."xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-07-104042"xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/author | "MacEwan D.J."xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/author | "Rushworth S.A."xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/pages | "3793-3801"xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/title | "HO-1 underlies resistance of AML cells to TNF-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18202225 | http://purl.uniprot.org/core/volume | "111"xsd:string |
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