| http://purl.uniprot.org/citations/18202369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202369 | http://www.w3.org/2000/01/rdf-schema#comment | "There is a critical need for genetic methods for the inducible expression of transgenes in specific cells during development. A promising approach for this is the GeneSwitch GAL4 system of Drosophila. With GeneSwitch GAL4 the expression of upstream activating sequence (UAS) effector lines is controlled by a chimeric GAL4 protein that becomes active in the presence of the steroid RU486 (mifepristone). To improve the utility of this expression system, we performed a large-scale enhancer-trap screen for insertions that yielded nervous system expression. A total of 204 GeneSwitch GAL4 lines with various larval expression patterns in neurons, glia, and/or muscle fibers were identified for chromosomes I-III. All of the retained lines show increased activity when induced with RU486. Many of the lines reveal novel patterns of sensory neurons, interneurons, and glia. There were some tissue-specific differences in background expression, with muscles and glia being more likely to show activity in the absence of the inducing agent. However, >90% of the neuron-specific driver lines showed little or no background activity, making them particularly useful for inducible expression studies."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.081968"xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Davis R.L."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Keshishian H."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Osterwalder T."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Nicholson L."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Singh G.K."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/author | "Roman G.W."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/pages | "215-234"xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/title | "Spatial and temporal control of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers."xsd:string |
| http://purl.uniprot.org/citations/18202369 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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