| http://purl.uniprot.org/citations/18202370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18202370 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans embryos, specification of the germ lineage depends on PIE-1, a maternal protein that blocks mRNA transcription in germline blastomeres. Studies in mammalian cell culture have suggested that PIE-1 inhibits P-TEFb, a kinase that phosphorylates serine 2 in the carboxyl-terminal domain (CTD) repeats of RNA polymerase II during transcriptional elongation. We have tested this hypothesis using an in vivo complementation assay for PIE-1 function. Our results support the view that PIE-1 inhibits P-TEFb using the CTD-like motif YAPMAPT. This activity is required to block serine 2 phosphorylation in germline blastomeres, but unexpectedly is not essential for transcriptional repression or specification of the germline. We find that sequences outside of the YAPMAPT are required to inhibit serine 5 phosphorylation, and that this second inhibitory mechanism is essential for transcriptional repression and specification of the germ lineage. Our results suggest that PIE-1 uses partially redundant mechanisms to block transcription by targeting both the initiation and elongation phases of the transcription cycle."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.083212"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.083212"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/author | "Ghosh D."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/author | "Ghosh D."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/pages | "235-243"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/pages | "235-243"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/title | "Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/title | "Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation."xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/18202370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18202370 |
| http://purl.uniprot.org/citations/18202370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18202370 |
| http://purl.uniprot.org/citations/18202370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18202370 |
| http://purl.uniprot.org/citations/18202370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18202370 |
| http://purl.uniprot.org/uniprot/Q94131 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18202370 |
| http://purl.uniprot.org/uniprot/Q94131#attribution-1CFE944A7639608E643D69C2ADCAAA51 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18202370 |