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http://purl.uniprot.org/citations/18203313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18203313http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We conducted a case-case comparison study to estimate the attack-rate of reactive joint pain (JPrea) following intestinal infections, and evaluated whether the susceptibility and severity of joint symptoms was associated with the tissue-type HLA-B27.

Methods

Consecutive patients with positive fecal culture for Salmonella, Campylobacter, Yersinia, Shigella, and E. coli were addressed by questionnaires inquiring about gastrointestinal (GI) symptoms and the occurrence of joint pain in a previously healthy joint within 4 weeks after onset of infection. A blood sample was requested for HLA-B27 typing.

Results

Of 3146 patients invited, 2105 (67%) responded to the survey questionnaire. The triggering infections were Campylobacter, 1003; Salmonella, 619; E. coli, 290; Shigella, 102; and Yersinia, 91. JPrea was reported by 294 subjects: Campylobacter, 131 (13.1%); Salmonella, 104 (16.8%); Yersinia, 21 (23.1%); Shigella, 10 (9.8%); and E. coli, 28 (9.7%). There was a significant association between severity of gastroenteritis and development of arthralgia (p = 0.001). The odds ratio (OR) for JPrea in an HLA-B27-positive individual was 2.62 (95% CI 1.67-3.93) for the entire group. A significant association between JPrea and HLA-B27 was found for Salmonella, Shigella, and Yersinia; not, however, for Campylobacter and E. coli. HLA-B27-positive patients had a significantly increased risk for severe joint symptoms.

Conclusion

Our study shows that JPrea after GI infection is positively correlated to severity of GI symptoms. HLA-B27 is not associated with joint pain after Campylobacter. Intestinal E. coli seems to be an arthritogenic pathogen. A significant association between HLA-B27 and severity of joint pain was observed."xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/author"Krogfelt K.A."xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/author"Locht H."xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/author"Schiellerup P."xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/pages"480-487"xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/title"A comparison of self-reported joint symptoms following infection with different enteric pathogens: effect of HLA-B27."xsd:string
http://purl.uniprot.org/citations/18203313http://purl.uniprot.org/core/volume"35"xsd:string
http://purl.uniprot.org/citations/18203313http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18203313
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