| http://purl.uniprot.org/citations/18204079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18204079 | http://www.w3.org/2000/01/rdf-schema#comment | "Apc(Min/+) mouse, a mouse model for human familial adenomatosis polyposis, contains a truncating mutation in the Apc gene and spontaneously develops intestinal tumors. Our previous study revealed two distinct stages of tumorigenesis in the colon of Apc(Min/+) mouse: microadenomas and macroscopic tumors. Microadenomas already have lost their remaining allele of the Apc and all microadenomas show accumulation of beta-catenin, indicating that activation of the canonical Wnt pathway is an initiating event in the tumorigenesis. This study shows that expression of nuclear beta-catenin in macroscopic tumors is further upregulated in comparison with that in microadenomas. Furthermore, transcriptional activity of beta-catenin/T-cell factor (Tcf) signaling, assessed using beta-catenin/Tcf reporter transgenic mice, is higher in the macroscopic tumors than that in microadenomas. In addition, the expression level of Dickkopf-1, which is known to be a negative modifier of the canonical Wnt pathway, was reduced only in colon tumors. These results suggest that activation of beta-catenin/Tcf transcription plays a role not only in the initiation stage but also in the promotion stage of colon carcinogenesis in Apc(Min/+) mice."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgn001"xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Aoki H."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Sheng H."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Yamashita S."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Hirata A."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Hara A."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Oyama T."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Tomita H."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Hata K."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/author | "Kunisada T."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/pages | "666-672"xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/title | "Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice."xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/18204079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18204079 |
| http://purl.uniprot.org/citations/18204079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18204079 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-18204079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18204079 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-18204079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18204079 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-18204079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18204079 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-18204079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18204079 |