DESCRIBE <http://purl.uniprot.org/citations/18204200>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18204200	http://www.w3.org/2000/01/rdf-schema#comment	" Unlabelled A growing body of evidence suggests that early growth response-1 (Egr-1), a transcription factor, may function as a tumor suppressor. The aim of this study was to gain more evidence to support the role of Egr-1 in the suppression of cancer cell growth and to examine the potential correlation between Egr-1 and gelsolin. Materials and methods Histochemical staining coupled with breast cancer tissue arrays were used to examine the expression levels of Egr-1 and gelsolin. Reporter assays and gel shift were used to study the transcriptional activity of Egr-1 on the regulation of gelsolin. Results Our data showed that most normal mammary tissues expressed high levels of Egr-1, while the majority of breast cancer tissues expressed very small amounts of Egr-1. The expression pattern of Egr-1 in human breast cancer tissues was highly correlated with gelsolin expression. Induction of Egr-1 by serum stimulation accompanied the increase of gelsolin expression. In cells lacking the induction of Egr-1 in response to serum stimulation, gelsolin expression remained unchanged. Furthermore, gelsolin promoter activity was profoundly reduced in Egr-1 null mouse embryonic fibroblasts compared to Egr-1 wild-type mouse embryonic fibroblasts. Gel shift experiments indicated that Egr-1 can directly bind to the gelsolin promoter. Conclusion Our results suggest that Egr-1 may be an important breast cancer marker and that an as yet uncharacterized pathway involved in Egr-1 and gelsolin expression exists which leads to breast cancer cell development."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Huang R."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Li S."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Liu J."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Yang D."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Yang W."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Yao C."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Liu Y.G."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/author	"Huang R.P."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/date	"2007"xsd:gYear
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/name	"Cancer Genomics Proteomics"xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/pages	"377-385"xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/title	"Concurrent down-regulation of Egr-1 and gelsolin in the majority of human breast cancer cells."xsd:string
http://purl.uniprot.org/citations/18204200	http://purl.uniprot.org/core/volume	"4"xsd:string
http://purl.uniprot.org/citations/18204200	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18204200
http://purl.uniprot.org/citations/18204200	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18204200
http://purl.uniprot.org/uniprot/#_A0A0A0MS51-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_A0A089VKS7-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_A0A0A0MT01-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_A0A384MEF1-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_B3KS49-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_B4DVG0-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_B7Z4U6-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200
http://purl.uniprot.org/uniprot/#_B7Z6N2-mappedCitation-18204200	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18204200