| http://purl.uniprot.org/citations/18205703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18205703 | http://www.w3.org/2000/01/rdf-schema#comment | "Substance P, acting via its neurokinin 1 receptor (NK1 R), plays an important role in mediating a variety of inflammatory processes. Its interaction with chemokines is known to play a crucial role in the pathogenesis of acute pancreatitis. In pancreatic acinar cells, substance P stimulates the release of NFkappaB-driven chemokines. However, the signal transduction pathways by which substance P-NK1 R interaction induces chemokine production are still unclear. To that end, we went on to examine the participation of mitogen-activated protein kinases (MAPKs) in substance P-induced synthesis of pro-inflammatory chemokines, monocyte chemoanractant protein-1 (MCP-I), macrophage inflammatory protein-lalpha (MIP-lalpha) and macrophage inflammatory protein-2 (MIP-2), in pancreatic acini. In this study, we observed a time-dependent activation of ERK1/2, c-Jun N-terminal kinase (JNK), NFkappaB and activator protein-1 (AP-1) when pancreatic acini were stimulated with substance P. Moreover, substance P-induced ERK 1/2, JNK, NFkappaB and AP-1 activation as well as chemokine synthesis were blocked by pre-treatment with either extracellular signal-regulated protein kinase kinase 1 (MEK1) inhibitor or JNK inhibitor. In addition, substance P-induced activation of ERK 112, JNK, NFkappaB and AP-1-driven chemokine production were attenuated by CP96345, a selective NK1 R antagonist, in pancreatic acinar cells. Taken together, these results suggest that substance P-NK1 R induced chemokine production depends on the activation of MAPKs-mediated NFkappaB and AP-1 signalling pathways in mouse pancreatic acini."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1582-4934.2007.00086.x"xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/author | "Bhatia M."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/author | "Adhikari S."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/author | "Ramnath R.D."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/name | "J Cell Mol Med"xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/pages | "1326-1341"xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/title | "Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells."xsd:string |
| http://purl.uniprot.org/citations/18205703 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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