| http://purl.uniprot.org/citations/18207745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18207745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18207745 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria and peroxisomes share a number of common biochemical processes, including the beta oxidation of fatty acids and the scavenging of peroxides. Here, we identify a new outer-membrane mitochondria-anchored protein ligase (MAPL) containing a really interesting new gene (RING)-finger domain. Overexpression of MAPL leads to mitochondrial fragmentation, indicating a regulatory function controlling mitochondrial morphology. In addition, confocal- and electron-microscopy studies of MAPL-YFP led to the observation that MAPL is also incorporated within unique, DRP1-independent, 70-100 nm diameter mitochondria-derived vesicles (MDVs). Importantly, vesicles containing MAPL exclude another outer-membrane marker, TOM20, and vesicles containing TOM20 exclude MAPL, indicating that MDVs selectively incorporate their cargo. We further demonstrate that MAPL-containing vesicles fuse with a subset of peroxisomes, marking the first evidence for a direct relationship between these two functionally related organelles. In contrast, a distinct vesicle population labeled with TOM20 does not fuse with peroxisomes, indicating that the incorporation of specific cargo is a primary determinant of MDV fate. These data are the first to identify MAPL, describe and characterize MDVs, and define a new intracellular transport route between mitochondria and peroxisomes."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2007.12.038"xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2007.12.038"xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Rachubinski R.A."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Rachubinski R.A."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Andrade-Navarro M.A."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Andrade-Navarro M.A."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "McBride H.M."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "McBride H.M."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Schauss A.C."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Schauss A.C."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Braschi E."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Braschi E."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Zunino R."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Zunino R."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Neuspiel M."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Neuspiel M."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Rippstein P."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/author | "Rippstein P."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/18207745 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |