| http://purl.uniprot.org/citations/18212043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18212043 | http://www.w3.org/2000/01/rdf-schema#comment | "The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediates Rac1 activation in netrin-1 signaling. We found that Trio interacts with the netrin-1 receptor DCC in mouse embryonic brains and that netrin-1-induced Rac1 activation in brain is impaired in the absence of Trio. Trio(-/-) cortical neurons fail to extend neurites in response to netrin-1, while they are able to respond to glutamate. Accordingly, netrin-1-induced commissural axon outgrowth is reduced in Trio(-/-) spinal cord explants, and the guidance of commissural axons toward the floor plate is affected by the absence of Trio. The anterior commissure is absent in Trio-null embryos, and netrin-1/DCC-dependent axonal projections that form the internal capsule and the corpus callosum are defective in the mutants. Taken together, these findings establish Trio as a GEF that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00998-07"xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Piche C."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Debant A."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Chebli K."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Enslen H."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Briancon-Marjollet A."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Lamarche-Vane N."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Triki I."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Cloutier J.F."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Castellani V."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Ghogha A."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Fromont S."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Nawabi H."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/author | "Auziol C."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/pages | "2314-2323"xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/title | "Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance."xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18212043 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18212043 |
| http://purl.uniprot.org/citations/18212043 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18212043 |
| http://purl.uniprot.org/uniprot/#_Q14185-mappedCitation-18212043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212043 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRP6-mappedCitation-18212043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212043 |