| http://purl.uniprot.org/citations/18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18212059 | http://www.w3.org/2000/01/rdf-schema#comment | "Border cell migration during Drosophila melanogaster oogenesis is a highly pliable model for studying epithelial to mesenchymal transition and directional cell migration. The process involves delamination of a group of 6 to 10 follicle cells from the epithelium followed by guided migration and invasion through the nurse cell complex toward the oocyte. The guidance cue is mainly provided by the homolog of platelet-derived growth factor/vascular endothelial growth factor family of growth factor, or Pvf, emanating from the oocyte, although Drosophila epidermal growth factor receptor signaling also plays an auxiliary role. Earlier studies implicated a stringent control of the strength of Pvf-mediated signaling since both down-regulation of Pvf and overexpression of active Pvf receptor (Pvr) resulted in stalled border cell migration. Here we show that the metastasis suppressor gene homolog Nm23/awd is a negative regulator of border cell migration. Its down-regulation allows for optimal spatial signaling from two crucial pathways, Pvr and JAK/STAT. Its overexpression in the border cells results in stalled migration and can revert the phenotype of overexpressing constitutive Pvr or dominant-negative dynamin. This is a rare example demonstrating the relevance of a metastasis suppressor gene function utilized in a developmental process involving cell invasion."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01743-07"xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/author | "Hsu T."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/author | "Dammai V."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/author | "Nallamothu G."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/author | "Woolworth J.A."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/pages | "1964-1973"xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/title | "Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion."xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18212059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18212059 |
| http://purl.uniprot.org/citations/18212059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18212059 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_E1JHB6-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_E1JHB7-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_E1JHB8-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KGE1-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGI7-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |
| http://purl.uniprot.org/uniprot/#_A4V4I8-mappedCitation-18212059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212059 |