| http://purl.uniprot.org/citations/18212118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18212118 | http://www.w3.org/2000/01/rdf-schema#comment | "SAP (also named SH2D1A) is an intracellular adaptor molecule expressed in T cells, natural killer (NK) cells, and some B cells. The SAP gene is mutated in X-linked lymphoproliferative (XLP) disease, a human immunodeficiency characterized by a faulty immune response to Epstein-Barr virus infection. Previous reports documented severe defects in antibody production and germinal center (GC) formation in SAP-deficient humans and mice genetically engineered to lack SAP expression. However, in vitro studies and adoptive transfer experiments provided conflicting data as to whether this phenotype is caused by a functional defect resulting from SAP deficiency in T cells, B cells, or both. Here, we ascertained which cell types are responsible for this humoral immunity defect by using a conditional gene targeting approach. We also thoroughly examined the expression pattern of SAP in normal immune cells by using intracellular flow cytometry. The results showed that expression of SAP in T cells, but not in B cells or NK cells, is required and sufficient for SAP-dependent antibody production and GC formation. These data provide a critical insight into the mechanism by which SAP regulates humoral immunity. They also help elucidate the basis of a severe human immunodeficiency."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0710698105"xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Dong Z."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/author | "Zhong M.C."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/pages | "1273-1278"xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/title | "SAP expression in T cells, not in B cells, is required for humoral immunity."xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18212118 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18212118 |
| http://purl.uniprot.org/citations/18212118 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18212118 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-18212118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212118 |
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| http://purl.uniprot.org/uniprot/#_B2RWI0-mappedCitation-18212118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212118 |
| http://purl.uniprot.org/uniprot/#_K7YQB3-mappedCitation-18212118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212118 |
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| http://purl.uniprot.org/uniprot/#_P25918-mappedCitation-18212118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18212118 |
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