| http://purl.uniprot.org/citations/18215660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18215660 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-kappaB/RelA family of transcription factors regulates inducible transcription of a large number of genes in response to diverse stimuli. Little is known, however, about the location of NF-kappaB in the cytoplasm and the transport mechanism to the nucleus. We found that NF-kappaB is associated with the actin-binding protein alpha-actinin-4. NF-kappaB and alpha-actinin-4 co-localized along actin stress fibers and in membrane lamellae in A431 cells. After a 30-min stimulation with EGF or TNF-alpha, alpha-actinin-4 and p65 were found in the nucleus. Disruption of cytoskeleton by cytochalasin D prior to treatment with TNF-alpha led to increase of p65 nuclear translocation. Antibodies to p65 subunit of NF-kappaB co-immunoprecipitated alpha-actinin-4 from A431 cell lysates and nuclear extracts, but alpha-actinin-1 and beta-actin were not found in the precipitates. Affinity chromatography experiments displayed that p65 and p50 subunits of NF-kappaB can bind to matrix-bound chicken gizzard alpha-actinin. We suggest that the alpha-actinin-4 is important for the NF-kappaB nuclear translocation and its functions inside the nucleus."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2007.12.001"xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Magnusson K.E."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Pinaev G.P."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Tentler D.G."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Turoverova L.V."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Babakov V.N."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Bolshakova A.V."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Kropacheva I.V."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Petukhova O.A."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/author | "Podolskaya E.P."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/pages | "1030-1038"xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/title | "RelA/NF-kappaB transcription factor associates with alpha-actinin-4."xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/18215660 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18215660 |
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